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Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering

https://doi.org/10.1038/s41467-024-55137-6

Padilla, Marshall S; Mrksich, Kaitlin; Wang, Yiming; Haley, Rebecca M; Li, Jacqueline J; Han, Emily L; El-Mayta, Rakan; Kim, Emily H; Dias, Sofia; Gong, Ningqiang; et al (December 2025, Nature Communications)

Free, publicly-accessible full text available December 1, 2026
Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery

https://doi.org/10.1038/s41565-024-01747-6

Xue, Lulu; Zhao, Gan; Gong, Ningqiang; Han, Xuexiang; Shepherd, Sarah J; Xiong, Xinhong; Xiao, Zebin; Palanki, Rohan; Xu, Junchao; Swingle, Kelsey L; et al (January 2025, Nature Nanotechnology)

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